Alabaster, AL 35007
1-800-227-0651 or 205-663-2494
Fax 1-800-229-1004 or 205-663-0756
Orders:
Technical Questions:
General Information:
|
Diether
Phospholipids
|
Synthetic Products
|
| 1,2-O-Dialkyl-sn-Glycero-3-Phosphocholine | |
| Purity >99% | |
| Chain |
Product |
M.W. |
Catalog Number |
| C6 |
Di-O-Hexyl |
425.54 |
|
| C12 |
Di-O-Dodecyl |
593.86 |
|
| C13 |
Di-O-Tridecyl |
621.92 |
|
| C14 |
Di-O-Tetradecyl |
649.97 |
|
| C16 |
Di-O-Hexadecyl |
706.08 |
|
| C18 |
Di-O-Octadecyl |
762.18 |
|
| C18:1 |
Di-O-Octadecenyl |
758.16 |
|
| C18-C1* |
1-O-Octadecyl-2-O-Methyl (ET-18-OCH3) |
523.71 |
| Note: | This product has been shown to have strong anti-tumor and anti-metastatic
activity. This product is also a biologically active analog of platelet activating factor. |
| Specifications | ||
| TLC: | One phosphorus positive spot, ninhydrin negative | |
| HPLC: | >99% dialkyl compound | |
| Solubility | ||
| Soluble: | Chloroform, Alcohol, Toluene | |
| Insoluble: | Water, Acetone | |
| Stability | ||
| Storage: | -20°C | |
| Shelf Life: | 12 Months | |
References
- Heesbeen, E.C., Verdonck, L.F., Staal, G.E. & Rijksen, G., (1994),
"Protein kinase C is not involved in the cytotoxic action of 1-octadecyl-2-O-methyl-sn-glycerol-3-phosphocholine
in HL-60 and K562 cells", Biochemical Pharmacology 47,
1481-1488.
- Lohmeyer, M. & Bittman, R., (1994), "Antitumor ether and
alkyl phosphocholines", Drugs of the Future 19, 1021-1037.
- Shames, R., Ruis, N.M. & Valone, F.H., (1994), "Tumor necrosis
factor release by murine macrophages stimulated by the cytotoxic ether
lipid", Int'l J. Of Immunopharmacology 16, 335-343.
- Kosano, H., Yasutomo, Y., Kugai, N., Nagata, N., Inagaki, H., Tanaka,
S. & Takatani, O., (1990), "Inhibition of estradiol uptake
and transforming growth factor alpha secretion in human breast cancer
cell line MCF-7 by an alkyl-lysophospholipid", Cancer Research
50, 3172-3175.
- Bazill, G.W. & Dexter, T.M., (1990), "Role of endocytosis
in the action of ether lipids on WEHI-3B, HL60, and FDCP-mix A4 cells",
Cancer Research 50, 7505-7512.
Avanti also has Ether 14-0-PG•Na