Synthetic->Bioactive Lipids->Second Messenger Lipids |
| Inositol Phosphates |
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D-myo-inositol-1,3,4-trisphosphate (ammonium salt) (IP3(1,3,4)) |
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D-myo-inositol-1,3,5-triphosphate (ammonium salt) (IP3(1,3,5)) |
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D-myo-inositol-1,4,5-triphosphate (ammonium salt) (IP3(1,4,5)) |
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D-myo-inositol-1,3,4,5-tetraphosphate (ammonium salt) (IP4(1,3,4,5)) |
The hydrophobic headgroup of membrane inositol phospholipids is a cyclic molecule with
six hydroxyl groups; the action of kinases on this inositol ring creates a variety of
phosphoinositols.
Inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) is produced by stimulation of
various cell surface receptors through phospholipase C activation, and the IP3 and DAG in
turn trigger Ca2+ release through IP3 receptors and protein kinase C activation, respectively.
The amount of IP3 produced is particularly critical to determining the spatio-temporally
coordinated Ca2+-signaling patterns.
GPCR agonists induced phosphoinositide turnover may be assessed by accumulation of
inositol phosphates.
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IP3(1,3,4) |
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D-myo-inositol-1,3,4-trisphosphate (ammonium salt) |
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| Catalog
Number |
Molecular
Weight |
|
|
850113 |
471.19 |
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More |
|
IP3(1,3,5) |
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D-myo-inositol-1,3,5-triphosphate (ammonium salt) |
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| Catalog
Number |
Molecular
Weight |
|
|
850114 |
471.19 |
Learn
More |
|
IP3(1,4,5) |
|
D-myo-inositol-1,4,5-triphosphate (ammonium salt) |
|
| Catalog
Number |
Molecular
Weight |
|
|
850115 |
471.19 |
Learn
More |
|
IP4(1,3,4,5) |
|
D-myo-inositol-1,3,4,5-tetraphosphate (ammonium salt) |
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| Catalog
Number |
Molecular
Weight |
|
|
850116 |
568.20 |
Learn
More |
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