Natural Products

Platelet-Activation Factor (PAF)

[Ether Ester Analog of Phosphatidylcholine] [Antihypertensive Polar Renomedullary Lipid (APRL)]

Purity >99%

PAF - 1-alkyl-2-acetoyl- sn-glycero-3-phosphocholine

Lyso PAF - 1-alkyl-2-hydroxy- sn-glycero-3-phosphocholine

Source M.W. Physical State Catalog Number 1-alkyl-2-acetoyl- sn-glycero-3-phosphocholine 523.69* Chloroform 840009 Product Data 1-alkyl-2-hydroxy- sn-glycero-3-phosphocholine 481.65** Chloroform 840008 Product Data * Based on 1-O-Hexadecyl-2-Acetoyl ** Based on 1-O-Hexadecyl-2-Hydroxy Specifications TLC: One phosphorus positive spot, ninhydrin negative Solubility Soluble: Chloroform, Methanol Insoluble: Acetone, Water Stability Storage: -20°C Shelf Life: 12 Months Preparation An ether ester analog of phosphatidylcholine prepared from fresh beef heart. The alkyl chain is mainly C16 and C18. Notes The alkyl lipid analog has been found to possess powerful antihypertensive properties. Also, it is reported to cause platelets to change shape, aggregate, and release their granule contents at concentrations between 10-11 and 10-10M. These products migrate between diacyl-sn-glycerol-3-phosphocholine on thin layer chromatography using chloroform:methanol:water (65/25/4) as solvent. References Blank, M.L., Snyder, F., Byers, L.M., Brooks, B. & Muirhead, E.E., (1979), "Antihypertensive activity of an alkyl ether analog of phosphatidylcholine," Biochem. Biophys. Res. Commun. 90, 1194-1200. Demopoulous, C.A., Pinckard, R.N. & Hanahan, D.J., (1979), "Platelet-activating factor. Evidence for 1-O-alkyl-2-acetoyl-sn-glycerol-3-phosphorylcholine as the active component (a new class of lipid chemical mediators)" J. Biol. Chem. 254, 9355-9358. Benveniste, J., Tence, M., Varenne, P., Bidault, J., Boullet, C., Polonsky, J. & Hebd, C.R., "Semi-synthesis and Proposed structure of platelet-activation factor (PAF). PAF-acether an alkyl ether analog of lysophosphatidylcholine" Seances Acad. Sci,, SerIII: Sci. Vie. 289, 1037-1040. Material Safety Information: Compounds should be treated as hazardous and used only under supervision of a competent investigator. Avoid all contact with skin and avoid breathing vapors Click Here For Synthetic PAF