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Synthetic Products
Synthetic Unsaturated PIP3
Purity >99%
The Purest Available Synthetic Unsaturated PIP3 with Biological Compatibility.
Product
M.W.
Catalog Number
 
18:1 PI(3,4,5)P3
1,171.18
850156
Product Data
18:0-20:4 PI(3,4,5)P3
1,195.20
850166
Product Data
18:1-12:0 Biotin PI(3,4,5)P3
1,350.15
860568
Product Data
18:1-12:0 (N-6:0 NBD) PI(3,4,5)P3
1,380.30
810183
Product Data
6:0 PI(3,4,5)P3
838.57
850176
Product Data


Phosphatidylinositols are important in intracellular signaling. In response to extracellular signals, these
molecules undergo rapid turnover and generate second messengers including DG, Ins 1,4,5-P3,
PtdIns 3,4-P2 and PtdIns 3,4,5-P3.


PIP3 Signaling In B Lymphocytes

PIP3 Signaling In Cardiac Myocytes

References:

  1. Wang J, Gambhir A, Hangyas-Mihalyne G, Murray D, Golebiewska U, McLaughlin S. (2002).
    Lateral sequestration of phosphatidylinositol 4,5-bisphosphate by the basic effector domain of myristoylated alanine-rich C kinase substrate is due to nonspecific electrostatic interactions.
    J Biol Chem. 277(37):34401-12.
  2. McLaughlin S, Wang J, Gambhir A, Murray D. (2002).
    PIP(2) and proteins: interactions, organization, and information flow.
    Annu Rev Biophys Biomol Struct. 31:151-75.
  3. Nasuhoglu C, Feng S, Mao J, Yamamoto M, Yin HL, Earnest S, Barylko B, Albanesi JP, Hilgemann DW. (2002).
    Nonradioactive analysis of phosphatidylinositides and other anionic phospholipids by anion-exchange high-performance liquid chromatography with suppressed conductivity detection.
    Anal Biochem. 301(2):243-54.
  4. Venkateswarlu K, Brandom KG, Lawrence JL. (2004).
    Centaurin-{alpha}1 Is an in Vivo Phosphatidylinositol 3,4,5-Trisphosphate-dependent GTPase-activating Protein for ARF6 That Is Involved in Actin Cytoskeleton Organization.
    J Biol Chem. 279(8):6205-6208.
  5. Tisi R, Belotti F, Wera S, Winderickx J, Thevelein JM, Martegani E. (2004).
    Evidence for inositol triphosphate as a second messenger for glucose-induced calcium signalling in budding yeast.
    Curr Genet. 45(2):83-9.
  6. Godecke A. (2003).
    PAF, PIP(3) and NO: emerging role in reperfusion injury.
    Cardiovasc Res. 60(2):215-6.
  7. Ishii M, Kurachi Y. (2003).
    Physiological actions of regulators of G-protein signaling (RGS) proteins.
    Life Sci. 74(2-3):163-71.
  8. Katakowski M, Zhang ZG, Chen J, Zhang R, Wang Y, Jiang H, Zhang L, Robin A, Li Y, Chopp M. (2003).
    Phosphoinositide 3-kinase promotes adult subventricular neuroblast migration after stroke.
    J Neurosci Res. 74(4):494-501.
  9. Kumar N, Zhao P, Tomar A, Galea CA, Khurana S. (2004).
    Association of villin with phosphatidylinositol 4,5-bisphosphate regulates the actin cytoskeleton.
    J Biol Chem. 279(4):3096-110.
  10. Powell DJ, Hajduch E, Kular G, Hundal HS. (2003).
    Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism.
    Mol Cell Biol. 23(21):7794-808.
  11. Beeson M, Sajan MP, Dizon M, Grebenev D, Gomez-Daspet J, Miura A, Kanoh Y, Powe J, Bandyopadhyay G, Standaert ML, Farese RV. (2003).
    Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise.
    Diabetes. 2003 Aug;52(8):1926-34.

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