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Synthetic Products
Alkyl Phosphocholine
12:0 Phosphocholine
Dodecylphosphocholine  

Catalog Number
Molecular Weight
Purity
 
850336
351.47
>99%
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16:0 Phosphocholine
Hexadecylphosphocholine
Miltefosine
 

Catalog Number
Molecular Weight
Purity
 
850337
407.57
>99%
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Specifications of Alkyl Phosphocholine
Physical Examination
TLC: One iodine positive and phosphorus positive spot.
HPLC: >99% (AUC) of phosphocholine
FTIR: Correspond to appropriate reference standard
Solubility
Soluble: ethanol, methanol, chloroform, dimethyl sulfoxide
Insoluble: water
Stability
Shelf Life: Saturated, 12 months ~ Unsaturated, 6 months
Storage: -20°C

References

  1. Bhattacharya SK, Jha TK, Sundar S, Thakur CP, Engel J, Sindermann H, Junge K, Karbwang J, Bryceson AD, Berman JD.
    (2004)
    Efficacy and tolerability of miltefosine for childhood visceral leishmaniasis in India.
    Clin Infect Dis. 2004 Jan 15;38(2):217-21. Epub 2003 Dec 18.
    [PubMed]
  2. Thornton, K. & Gorenstein, D.G.
    (1994)
    Structure of glucagon-like peptide (7-36) amide in a dodecyl-phosphocholine micelle as determined by 2D NMR
    Biochemistry 33, 3532-3539.

  3. Peters, A.R., Dekker, N., van den Berg, L., Boelens, R., Kaptein, R., Slotboom, A.J. & de Haas, G.H.,(1992)
    Conformational changes in phospholipase A2 upon binding to micellar interfaces in the absence and presence of competitive inhibitors. A 1H and 15N NMR study
    Biochemistry 31, 10024-10030.

  4. Lohmeyer, M. & Bittman, R., (1994)
    Antitumor ether lipids and alkyl phosphocholines
    Drugs of the Future 19, 1021-1037.

  5. Geilen, C.C., Wieder, T., Haase, A., Reutter, W., Morre, D.M. & Morre, D.J.,(1994)
    Uptake, subcellular distribution and metabolism of the phospholipid analogue hexadecyl-phosphocholine in MDCK cells
    Biochimica et Biophysica Acta 1211, 14-22.

  6. Kaufmann-Kolle, P., Drevs, J., Berger, M.R., Kotting, J., Marschner, N., Unger, C. & Eibl, H., (1994)
    Pharmacokinetic behavior and antineoplastic activity of liposomal-hexadecylphosphocholine
    Cancer Chemotherapy & Pharmacology 34, 393-398.

  7. Dummer, R., Krasovec, M., Roger, J., Sindermann, H. & Burg, G., (1993)
    Topical administration of hexadecyl-phosphocholine in patients with cutaneous lymphomas: results of a phase I/II study
    J. Of the American Academy of Dermatology 29, 963-970.

     
  8. Geilen, C.C., T. Wieder, and W. Reutter. (1992).
    Hexadecylphosphocholine inhibits translocation of CTP:choline-phosphate cytidylyltransferase in Madin-Darby canine kidney cells.
    J Biol Chem
    267:6719-24.
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