Chain	Acyl Group	M.W.	Catalog Number
14:0	Tetramyristoyl	1,275.71	710332*	Product Data
14:0	Tetramyristoyl	1,285.62	750332**	Product Data
18:1	Tetraoleoyl	1,501.98	710335	Product Data

Specifications for 1,1',2,2'-Tetra-Acyl-Cardiolipin
Physical Examination
	TLC:	One phosphorus positive spot
	HPLC:	>99% tetra-acyl compound
Solubility
	Soluble:	Chloroform, Alcohol** (warmed)
	Insoluble:	Water, Acetone **Water content 3-5%, concentration up to 10mg/ml.
Stability
	Storage:	-20°C
	Shelf Life:	Tetramyristoyl - 12 Months ~ Tetraoleoyl - 6 Months
Preparation
	This synthetic product is made in Avanti's laboratory.

Reference List

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2. Lutter, M., M. Fang, X. Luo, M. Nishijima, X.s. Xie, and X. Wang. (2000). Cardiolipin provides specificity for targeting of tBid to mitochondria. Nat Cell Biol 2:754-61.
3. Megli, F.M., M. Mattiazzi, T. Di Tullio, and E. Quagliariello. (2000). Annexin V binding perturbs the cardiolipin fluidity gradient in isolated mitochondria. Can it affect mitochondrial function? Biochemistry 39:5534-42.
4. Gonzalez, B., M. Iturralde, M.A. Alava, A. Anel, and A. Pineiro. (2000). Metabolism of n -9, n -6 and n -3 fatty acids in hepatoma Morris 7777 cells. Preferential accumulation of linoleic acid in cardiolipin. Prostaglandins Leukot Essent Fatty Acids 62:299-306.
5. Paradies, G., G. Petrosillo, M. Pistolese, and F.M. Ruggiero. (2000). The effect of reactive oxygen species generated from the mitochondrial electron transport chain on the cytochrome c oxidase activity and on the cardiolipin content in bovine heart submitochondrial particles. FEBS Lett 466:323-6.
6. Sedlak, E. and N.C. Robinson. (1999). Phospholipase A(2) digestion of cardiolipin bound to bovine cytochrome c oxidase alters both activity and quaternary structure. Biochemistry 38:14966-72.
7. Ortiz, A., J.A. Killian, A.J. Verkleij, and J. Wilschut. (1999). Membrane fusion and the lamellar-to-inverted-hexagonal phase transition in cardiolipin vesicle systems induced by divalent cations. Biophys J 77:2003-14.
8. Aguilar, L., G. Ortega-Pierres, B. Campos, R. Fonseca, M. Ibanez, C. Wong, N. Farfan, J.M. Naciff, M.A. Kaetzel, J.R. Dedman, and I. Baeza. (1999). Phospholipid membranes form specific nonbilayer molecular arrangements that are antigenic. J Biol Chem 274:25193-6.
9. Gomez, B. Jr and N.C. Robinson. (1999). Phospholipase digestion of bound cardiolipin reversibly inactivates bovine cytochrome bc1. Biochemistry 38:9031-8.
10. Gomez, B.J.r. and N.C. Robinson. (1999). Quantitative determination of cardiolipin in mitochondrial electron transferring complexes by silicic acid high-performance liquid chromatography. Anal Biochem 267:212-6.
11. Watkins, S.M., L.C. Carter, and J.B. German. (1998). Docosahexaenoic acid accumulates in cardiolipin and enhances HT-29 cell oxidant production. J Lipid Res 39:1583-8.
12. Hatch, G.M. and G. McClarty. (1998). Cardiolipin remodeling in eukaryotic cells infected with Chlamydia trachomatis is linked to elevated mitochondrial metabolism. Biochem Biophys Res Commun 243:356-60.
13. Hatch, G.M. (1998). Cardiolipin: biosynthesis, remodeling and trafficking in the heart and mammalian cells (Review). Int J Mol Med 1:33-41.