Synthetic Products |
Sphingolipids |
| D-erythro-Ceramide-1-Phosphate |
Purity >99% |
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Product |
M.W. |
Catalog Number |
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N-Acetoyl (2:0) Ceramide-1-Phosphate, NH4+ |
438.54 |
860530 |
Product Data
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Product |
M.W. |
Catalog Number |
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N-Lauroyl-Ceramide-1-Phosphate (Ammonium Salt)
|
578.81 |
860531 |
Product Data
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Product |
M.W. |
Catalog Number |
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N-Octanoyl (8:0) Ceramide-1-Phosphate, NH4+ |
522.71 |
860532 |
Product Data
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|
Ceramide, a product of agonist-stimulated sphingomyelinase activation, is known to be generated during the phagocytosis of antibody-coated erythrocytes by polymorphonuclear leukocytes. Agonist-stimulated formation of ceramide-1-phosphate is now shown to occur in 32PO4-labeled neutrophils. Ceramide-1-phosphate is formed by a calcium-dependent ceramide kinase, found predominately in the neutrophil plasma membrane. Ceramide-1-phosphate may promote phagolysosome formation. 1 Ceramide-induced apoptosis was suppressed by insulin-like growth factor-I which is a strong promoter of cell growth and morphogenesis for the developing inner ear. In contrast, ceramide-1-phosphate protected the explants from apoptosis induced by serum withdrawal but did not antagonise ceramide-induced cell death. This study suggests that sphingomyelin-derived second messengers might be modulators of programmed cell death during development. 2 |
References:
- Hinkovska Galcheva VT; Boxer LA; Mansfield PJ; Harsh D; Blackwood A; Shayman JA; (1998), The formation of ceramide1phosphate during neutrophil phagocytosis and its role in liposome fusion. J Biol Chem, 273:50, 33203
- Frago LM; León Y; de la Rosa EJ; Gómez Muñoz A; Varela Nieto I; (1998), Nerve growth factor and ceramides modulate cell death in the early developing inner ear. J Cell Sci, 111, 54956
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