| Separate Pools of Sphingosine
|
| This paper describes the possible existence of a pool of
gangliosidederived sphingosine, quite separate from the cell
basal pool of sphingosine, suggesting that sphingosine derived
from sphingolipid catabolism is reduced to sphinganine before
entering the sphingolipid biosynthetic pathway. 1
|
| Sphinganine antagonism of PKC
|
| Triamcinoloneinduced reduction of PKC concentration coupled
with sphinganine antagonism of PKC activation contributed
to a synergistic growth inhibition of an androgen resistant
prostatic carcinoma. 2
|
| Sphinganine kinase activity in plant tissue
|
| The results of this study demonstrate, for the first time,
the presence of sphinganine kinase activity in plant tissue
and suggest that the properties of the kinase from corn microsomes
are distinct from those of the mammalian and protistan enzymes
in some respects. 3
|
| Three sphingolipiddependent mechanisms for inducing apoptosis
|
| These results illustrate three sphingolipiddependent mechanisms
for inducing apoptosis: accumulation of excess ceramide, accumulation
of excess sphinganine, and depletion of ceramide or complex
sphingolipids derived from ceramide. 4
|
|
References
- Chigorno V; Riva C; Valsecchi M; Nicolini M; Brocca
P; Sonnino S; (1997), Metabolic processing of gangliosides
by human fibroblasts in cultureformation and recycling
of separate pools of sphingosine. Eur J Biochem,
250:3, 6619
- Sosnowski J; Stetter Neel C; Cole D; Durham JP; Mawhinney
MG; (1997), Protein kinase C mediated antiproliferative
glucocorticoidsphinganine synergism in cultured Pollard
III prostate tumor cells. J Urol, 158:1, 26974
- Crowther GJ; Lynch DV; (1997), Characterization of
sphinganine kinase activity in corn shoot microsomes.
Arch Biochem Biophys, 337:2, 28490
- Tolleson WH; Couch LH; Melchior WB Jr; Jenkins GR; Muskhelishvili
M; Muskhelishvili L; McGarrity LJ; Domon O; Morris SM;
Howard PC; (1999), Fumonisin B1 induces apoptosis in cultured
human keratinocytes through sphing-anine accumulation
and ceramide depletion. Int J Oncol, 14:5, 83343
|
