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Sphingolipids
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| N,N,N-Trimethylsphingosine
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Product Name
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Product Number
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N,N,N-Trimethylsphingosine
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860497
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| Inhibitor of Platelet Activation |
| Trimethylsphingosine (TMS) is valuable in preventing in vitro
platelet activation and promises to be a useful preservative
for diagnostic testing of platelet activation.1
TMS and N,N-Dimethylsphingosine (DMS) could be useful reagents
to inhibit cell surface expression of crucial selectins which
promote adhesion of Le(x-) or sialosyl-Le(x)-expressing cells
with platelets and endothelial cells.2 |
| Cardioprotective Agent |
| TMS is a potent and effective cardioprotective agent that
inhibits leukocyte-endothelial cell interactions and preserves
cardiac contractile function and coronary perfusion following
myocardial ischemia and reperfusion.3 |
| Inhibitor of Tumor Growth |
| TMS and DMS had an inhibitory effect (via blocking of transmembrane
signaling) on the growth of various human tumor cell lines in
vitro. 4 |
| Inhibitor of PKC |
| TMS is a stronger inhibitor of PKC than Sphingosine or DMS
and is considerably less cytotoxic to neutrophils under the
same experimental conditions. 5, 6, 7 |
References:
- Kennedy SD; Igarashi
Y; Kickler TS; (1997), Measurement of in vitro
Pselectin expression by flow cytometry. Am J Clin Pathol,
107:1, 99104
- Handa K; Igarashi Y; Nisar M; Hakomori
S; (1991), Downregulation of GMP140 (CD62 or PADGEM) expression
on platelets by N,Ndimethyl and N,N,Ntrimethyl derivatives
of sphingosine. Biochemistry, 30:50, 116826
- Campbell B; Shin YK; Scalia R; Lefer
AM; (1998), Beneficial effects of N,N,Ntri-methylsphingosine
following ischemia and reperfusion in the isolated perfused
rat heart. Cardiovasc Res, 39:2, 393400
- Endo K; Igarashi Y; Nisar M; Zhou QH;
Hakomori S; (1991), Cell membrane signaling as target
in cancer therapy: inhibitory effect of N,Ndimethyl and
N,N,Ntrimethyl sphingosine derivatives on in vitro and
in vivo growth of human tumor cells in nude mice.
Cancer Res, 51:6, 16138
- Kimura S; Kawa S; Ruan F; Nisar M; Sadahira
Y; Hakomori S; Igarashi Y; (1992), Effect of sphingosine
and its Nmethyl derivatives on oxidative burst, phagokinetic
activity, and transendothelial migration of human neutrophils.
Biochem Pharmacol, 44:8, 158595
- Knöfler R; Urano T; Takada Y; Takada
A; (1994), N,N,Ntrimethylsphingosine modifies aggregatory
response and ATP release from platelets in whole blood.
Thromb Res, 76:4, 32332
- Park YS; Hakomori S; Kawa S; Ruan F;
Igarashi Y; (1994), Liposomal N,N,Ntrimethyl-sphingosine
(TMS) as an inhibitor of B16 melanoma cell growth and
metastasis with reduced toxicity and enhanced drug efficacy
compared to free TMS: cell membrane signaling as a target
in cancer therapy III. Cancer Res, 54:8, 22137
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