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Product Name
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Product Number
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N,N-Dimethylsphingosine
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860496
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Competitive Inhibitor of Sphingosine Kinase |
| Dimethylsphingosine (DMS) acts as a specific competitive inhibitor
of sphingosine kinase in diverse cell types and is a useful
tool to elucidate the role of SPP as an intracellular second
messenger. 1 |
| Induction of Apoptosis |
| Because sphingosine and DMS induce apoptosis regardless of
Pglycoprotein expression, they may provide a new strategy and
a promising approach to the treatment of anticancer drugresistant
cancer. 2 |
| Activation of caspase-3 like proteases in apoptosis |
| Results suggest that caspase3like proteases participate in
apoptotic cell death induced by sphingosine and other long chain
bases including DMS. 3 |
| Activation of Serine Kinase (SDK1) |
| SDK1 is a serine kinase with molecular mass 5060 kDa that
is strongly activated by N,Ndimethylsphingosine and sphingosine,
but not by ceramide, sphingosine-1phosphate, or other sphingo,
phospho, or glycerolipids tested. 4 |
| Competitive Inhibitor of Sphingosine Kinase |
| Dimethylsphingosine (DMS) acts as a specific competitive inhibitor
of sphingosine kinase in diverse cell types and is a useful
tool to elucidate the role of SPP as an intracellular second
messenger. 1 |
| Induction of Apoptosis |
| Because sphingosine and DMS induce apoptosis regardless of
Pglycoprotein expression, they may provide a new strategy and
a promising approach to the treatment of anticancer drugresistant
cancer. 2 |
| Activation of caspase-3 like proteases in apoptosis
|
| Results suggest that caspase3like proteases participate in
apoptotic cell death induced by sphingosine and other long chain
bases including DMS. 3 |
| Activation of Serine Kinase (SDK1) |
| SDK1 is a serine kinase with molecular mass 5060 kDa that
is strongly activated by N,Ndimethylsphingosine and sphingosine,
but not by ceramide, sphingosine-1phosphate, or other sphingo,
phospho, or glycerolipids tested. 4 |
References:
- Edsall LC; Van Brocklyn JR; Cuvillier O; Kleuser B; (1998),
Spiegel S; N,NDimethylsphingosine is a potent competitive
inhibitor of sphingosine kinase but not of protein kinase
C: modulation of cellular levels of sphingosine-1phosphate
and ceramide, Biochemistry, 37:37, 128928
- Shirahama T; Sweeney EA; Sakakura C; Singhal AK; Nishiyama
K; Akiyama S; Hakomori S; Igarashi Y; (1997), In vitro and
in vivo induction of apoptosis by sphingosine and N,Ndimethylsphingosine
in human epidermoid carcinoma KB31 and its multidrugresistant
cells, Clin Cancer Res, 3:2, 25764
- 3. Hung WC; Chang HC; Chuang LY ; (1999), Activation of
caspase-3like proteases in apoptosis induced by sphingosine
and other longchain bases in Hep3B hepatoma cells, Biochem
J, 338 ( Pt 1):, 1616
- 4. Megidish T; Cooper J; Zhang L; Fu H; Hakomori S; (1998),
A novel sphingosinedependent protein kinase (SDK1) specifically
phosphorylates certain isoforms of 1433 protein, J Biol
Chem, 273:34, 2183445
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