| Synthetic Products
|
| Phosphatidic Acid |
|
Purity
> 99%
|
| Typical Phosphatidic Acid Structure |
|
|
|
1,2-Dimyristoyl-sn-Glycero-3-Phosphate (Monosodium
Salt)
|
Specifications for Purified Phosphatidic
Acid
Physical Examination:
| |
Powder: |
White solid which contains no foreign matter and no more than
a faint odor. |
| |
Organic Solution: |
Clear, colorless solution which contains no foreign matter. |
Identification:
| |
GC: |
The retention time of the principal peak of the sample chromatogram
agrees with that of the chromatogram for the reference standard. |
|
TLC: |
the Rf value and general appearance of the principal
spot in the sample chromatogram agrees with that of the reference
standard |
| |
HPLC: |
The retention time of the principal peak of the sample chromatogram
agrees with that of the chromatogram for the reference standard. |
| |
FTIR: |
The infrared absorption spectrum of the sample exhibits maxima
only at the same wavelengths as that of the standard between
the regions of 4000-500 cm-1. |
| |
UV/Visible: |
The UV/Visible absorbtion spectrum of the sample exhibits
maxima only at the same wavelengths as that of the standard
between the regions of 190-820 nm. |
Chromatographic Purity:
|
GC: |
Not less than 99.0% (AUC) |
|
HPLC: |
Not less than 99.0% (AUC) |
Solubility
|
Short
Chain (C6-C8) |
|
|
Soluble: Chloroform, Water |
|
|
Insoluble: Acetone |
|
Long Chain Saturated
(C10-C18) |
|
|
Soluble: Chloroform, Toluene |
|
|
Insoluble: Acetone, Methanol, Ethanol, Water |
|
Long
Chain Unsaturated
(C10-C18) |
|
|
Soluble: Chloroform, Toluene |
|
|
Insoluble: Acetone, Methanol, Ethanol, Water |
Stability
| |
Storage: |
-20°C |
|
Shelf Life: |
3 Months - Polyene
~ 6 Months - Monoene
~ 12 Months- Saturated |
Description
The list of phosphatidic acid products offered by Avanti is designed
to provide compounds having a variety of physical properties. Products
available include short chain (C6-C8; water soluble), saturated,
multi-unsaturated and mixed acid PA's. All of the products are purified
by HPLC, and special precautions are taken to protect them from
oxidization and hydrolysis. Several of these products are manufactured
under cGMP guidelines and are available for your pharmaceutical use. If you have a requirement for
a phosphatidic acid derivative not found in our list, please call.
Note
Due to the high transition temperatures of saturated products, it
may be necessary to heat the solvent to solubilize the compound.
Also, a small amount of methanol (0.1%) and water (0.05%) may be
needed to hydrate the compound.
References
- Lin, B.Z., Yin, C.C. & Hauser, H., (1993), "The Effect
of Positive and Negative pH-gradients on the Stability of Small
Unilamellar Vesicles of Negatively Charged Phospholipids",
Biochim. Biophys. Acta 1147, 237-244.
- Larsen, C.E., Nir, S., Alford, D.R., Jennings, M., Lee, K. &
Duzgunes, N., (1993), "Human Immunodeficiency Virus Type
I (HIV-1) Fusion with Model Membranes: Kinetic Analysis and the
Role of Lipid Composition, pH and Divalent Cations", Biochim.
Biophys. Acta 1147, 223-236.
- Senisterra GA, van Gorkom LC, Epand RM., (1993), "Calcium-independent activation of protein kinase C by the dianionic form of phosphatidic acid.",Biochem Biophys Res Commun. 1993 Jan 15;190(1):33-6.
Phosphatidic Acid (Asymmetric
Fatty Acid)
1-Acyl-2-Acyl-sn-Glycero-3-Phosphate
(Monosodium Salt)
|
Carbon Number
|
1-Acyl
|
2-Acyl
|
M.W.
|
Catalog Number
|
|
|
16:0-18:1
|
Palmitoyl
|
Oleoyl
|
696.92
|
840857
|
|
|
16:0-18:2
|
Palmitoyl
|
Linoleoyl
|
694.91
|
840858
|
|
|
16:0-20:4
|
Palmitoyl
|
Arachidonoyl
|
718.93
|
840859
|
|
|
16:0-22:6
|
Palmitoyl
|
Docosahexaenoyl
|
742.95
|
840860
|
|
|
18:0-18:1
|
Stearoyl
|
Oleoyl
|
724.98
|
840861
|
|
|
18:0-18:2
|
Stearoyl
|
Linoleoyl
|
722.96
|
840862
|
|
|
18:0-20:4
|
Stearoyl
|
Arachidonoyl
|
746.98
|
840863
|
|
|
18:0-22:6
|
Stearoyl
|
Docosahexaenoyl
|
771.00
|
840864
|
|
Specify Chloroform or Powder for these
products
Phosphatidic Acid (Symmetric Fatty Acid)
1,2-Diacyl-sn-Glycero-3-Phosphate
(Monosodium Salt)
| Carbon
Number |
Product |
M.W. |
Catalog
Number |
|
| 6:0 |
Dicaproyl |
390.35 |
830841 |
|
| 8:0 |
Dicapryloyl |
446.45 |
830842 |
|
| 10:0 |
Dicapryl |
502.56 |
830843 |
|
| 12:0 |
Dilauroyl |
557.67 |
840635 |
|
| 14:0 |
Dimyristoyl |
614.78 |
830845 |
|
| 16:0 |
Dipalmitoyl |
670.88 |
830855 |
|
| 16:0[(CH3)4] |
Diphytanoyl |
783.10 |
850406 |
|
|
17:0
|
Diheptadecanoyl
|
698.94
|
830856
|
Product Data |
| 18:0 |
Distearoyl |
726.99 |
830865 |
|
| 18:1 |
Dioleoyl |
722.96 |
840875 |
|
| 18:2 |
Dilinoleoyl |
718.93 |
840885 |
|
| 20:4 |
Diarachidonoyl |
766.97 |
840886 |
|
| 22:6 |
Didocosahexaenoyl |
815.01
|
840887 |
|
Specify Chloroform or Powder for these products
|
