Synthetic
Products |
| Phosphatidylglycerol |
Purity
> 99% |
| Typical Phosphatidylglycerol Structure |
|
1,2-dimyristoyl-sn-glycero-3-[phospho-rac-(1-glycerol)]
(sodium salt)
|
Specifications
for Purified Phosphatidylglycerol |
| Physical Examination: |
|
Powder: |
White solid which contains no foreign matter and no
more than a faint odor. |
|
Organic Solution: |
Clear, colorless solution which contains no foreign
matter. |
| Identification: |
|
GC: |
The retention time of the principal peak of the sample
chromatogram agrees with that of the chromatogram for
the reference standard |
|
TLC: |
The Rf value and general appearance of the
principal spot in the sample chromatogram agrees with
that of the reference standard. |
|
HPLC: |
The retention time of the principal peak of the sample
chromatogram agrees with that of the chromatogram for
the reference standard. |
|
FTIR: |
The infrared absorption spectrum of the sample exhibits
maxima only at the same wavelengths as that of the standard
between the regions of 4000-500cm-1. |
|
UV/Visible: |
The UV/Visible absorption spectrum of the sample exhibits
maxima only at the same wavelengths as that of the standard
between the regions of 190-820 nm. |
| Chromatographic Purity: |
|
GC: |
Not less than 99.0 Percent (AUC) |
|
HPLC: |
Not less than 99.0 percent (AUC) |
| Solubility: |
|
Short Chain (C6-C8) |
|
Soluble: |
Chloroform, Water |
|
Insoluble: |
Acetone |
|
Long Chain Saturated
(C10-C18) |
|
Soluble: |
Chloroform, Toluene |
|
Insoluble: |
Acetone, Methanol, Ethanol, Water |
|
Long Chain Unsaturated
(C10 - C18) |
|
Soluble: |
Chloroform, Toluene |
|
Insoluble: |
Acetone, Methanol, Ethanol,Water |
| Stability |
|
Storage: |
-20°C |
|
Shelf Life: |
3 Months - Polyene
~ 6 Months - Monoene
~ 12 Months - Saturated |
Description
The list of phosphatidylglycerol products offered by Avanti
is designed to provide compounds having a variety of physical
properties. Products available include short chain (C6-C8;
water soluble), saturated, multi-unsaturated and mixed acid PG's. All of
the products are purified by HPLC, and special precautions
are taken to protect them from oxidization and hydrolysis.
Several of these products are manufactured under cGMP guidelines
and are available for your pharmaceutical
use. If you have a requirement for a glycerol derivative
not found in our list, please call.
Note
Due to the high transition temperatures of saturated products,
it may be necessary to heat the solvent to solubilize the
compound. Also, a small amount of methanol (0.1%) and water
(0.05%) may be needed to hydrate the compound.
Reference
- Lopez-Berestein, G., Kais, L., Rosenblum, M.G., Haynie,
T., & Jahns, M. et al., (1984), "Clinical Pharmacology
of 99mtc-labeled Liposomes in Patients with Cancer", Cancer Research 44 (January), 375-378.
- Lopez-Berestein, G.,Fainstein, V., Hopfer, R., Mehta K.
& Sullivan, M.P. et al., (1985), "Liposomal Amphotericin
B for the Treatment of Systemic Fungal infections in Patients
with Cancer: A Preliminary Study", The Journal of
Infectious Diseases 1, 51 (April), 704-710.
- Lopez-Berestein, G., McQueen, T. & Mehta, K., (1985),
"Protective Effect of Liposomal-Amphotericin B Against
C Albicans Infections in Mice", Cancer Drug Delivery 2, 183-189.
Phosphatidylglycerol (Asymmetric
Fatty Acid)
1-Acyl-2-Acyl-sn-Glycero-3-[Phospho- rac-(1-glycerol)]
(Sodium Salt)
Carbon Number |
1-Acyl |
2-Acyl |
M.W. |
Catalog Number |
|
16:0-18:1 |
Palmitoyl |
Oleoyl |
771.00 |
840457 |
|
16:0-18:2 |
Palmitoyl |
Linoleoyl |
768.99 |
840497 |
|
16:0-20:4 |
Palmitoyl |
Arachidonoyl |
793.01 |
840499 |
|
16:0-22:6 |
Palmitoyl |
Docosahexaenoyl |
817.03 |
840500 |
|
18:0-18:1 |
Stearoyl |
Oleoyl |
799.05 |
840503 |
|
18:0-18:2 |
Stearoyl |
Linoleoyl |
797.04 |
840504 |
|
18:0-20:4 |
Stearoyl |
Arachidonoyl |
821.06 |
840505 |
|
18:0-22:6 |
Stearoyl |
Docosahexaenoyl |
845.08 |
840506 |
|
Phosphatidylglycerol (Symmetric Fatty Acid)
1,2-Diacyl-sn-Glycero-3-[Phospho- rac-(1-glycerol)]
(Sodium Salt)
Chain |
Product |
M.W. |
Catalog
Number |
|
|
6:0 |
Dicaproyl |
464.43 |
840432 |
|
|
8:0 |
Dioctanoyl |
520.53 |
840433 |
|
|
10:0 |
Dicapryl |
576.64 |
840434 |
|
|
12:0 |
Dilauroyl |
632.75 |
840435 |
|
|
14:0 |
Dimyristoyl |
688.86 |
840445 |
|
|
16:0 |
Dipalmitoyl |
744.96 |
840455 |
|
|
16:0[(CH3)4] |
Diphytanoyl |
857.18 |
850404 |
|
|
|
17:0
|
Diheptadecanoyl
|
773.02
|
830456C
|
Chloroform
|
|
|
17:0
|
Diheptadecanoyl
|
773.02
|
830456P
|
Powder
|
|
18:0 |
Distearoyl |
801.07 |
840465 |
|
|
18:1 (delta9 cis) |
Dioleoyl |
797.04 |
840475 |
|
|
18:1(delta9 trans) |
Dielaidoyl |
797.04 |
840477 |
|
|
18:2 |
Dilinoleoyl |
793.01 |
840485 |
|
|
18:3 |
Dilinolenoyl |
788.98 |
840487 |
|
|
20:4 |
Diarachidonoyl |
841.05 |
840490 |
|
|
22:6 |
Docosahexaenoyl |
889.10
|
840492 |
|
|
Specify Chloroform or Powder on these
products
|
