Alabaster, AL 35007
1-800-227-0651 or 205-663-2494
Fax 1-800-229-1004 or 205-663-0756
Orders:
Technical Questions:
General Information:
|
Synthetic Products
|
| Phosphatidylserine |
|
Purity > 99%
|
| Typical Phosphatidylserine Structure |
|
1,2-Dimyristoyl-sn-Glycero-3-[Phospho-L-Serine]
(Sodium Salt)
|
|
Specifications
for Purified Phosphatidylserine
|
| Physical Examination: | ||
| Powder: | White solid which contains no foreign matter and no more than a faint odor. | |
| Organic solution: | Clear, colorless solution which contains no foreign matter. | |
| Identification: | ||
| GC: | The retention time of the principal peak of the sample chromatogram agrees with that of the chromatogram for the reference standard. | |
| TLC: | The Rf value and general appearance of the principal spot in the sample chromatogram agrees with that of the reference standard. | |
| HPLC: | The retention time of the principal peak of the sample chromatogram agrees with that of the chromatogram for the reference standard. | |
| FTIR: | The infrared absorption spectrum of the sample exhibits maxima only at the same wavelengths as that of the standard between the regions of 4000-500 cm-1. | |
| UV/Visible: | The UV/Visible absorption spectrum of the sample exhibits maxima only at the same wavelengths as that of the standard between the regions of 190-820 nm. | |
| Chromatographic Purity: | ||
| GC: | Not less than 99.0 percent (AUC). | |
| HPLC: | Not less than 99.0 percent (AUC). | |
| Solubility | ||
| Short Chain (C6-C8) | ||
| Soluble: | Chloroform, Water | |
| Insoluble: | Acetone | |
| Long Chain Saturated (C10-18) | ||
| Soluble: | Chloroform, Toluene | |
| Insoluble: | Acetone, Methanol, Ethanol, Water | |
| Long Chain Unsaturated (C10-C18) | ||
| Soluble: | Chloroform, Toluene | |
| Insoluble: | Acetone, Methanol, Ethanol, Water | |
| Stability | ||
| Storage: | -20°C | |
| Shelf Life: | ~3 Months - Polyene ~ 6 Months - Monoene ~ 12 Months - Saturated |
|
Note
Due to the high transition temperatures of saturated products, it may be necessary to heat the solvent to solubilize the compound. Also, a small amount of methanol (0.1%) and water (0.05%) may be needed to hydrate the compound.
Description
The list of phosphatidylserine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C6-C8); water soluble), saturated, multi-unsaturated and mixed acid PS's. All of the products are purified by HPLC, and special precautions are taken to protect the products from oxidization and hydrolysis. Several of these products are manufactured under GMP guidelines and are available for your pharmaceutical use. If you have a requirement for a serine derivative not found in our list, please call.
References
Düzgünes, N., Wilschut, J. Fraley, R. & Papahadjopoulas, D., (1981), "Studies on the Mechanism of Membrane Fusion: Role of Headgroup Compositions in Calcium and Magnesiuminduced Fusion of Mixed Phospholipid Vesicles", Biochim. Biophys. Acta 642, 182195.
Phosphatidylserine (Asymmetric Fatty Acid)
1-Acyl-2-Acyl-sn-Glycero-3-[Phospho-L-Serine] (Sodium Salt)
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Chain
|
Chain 1
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Chain 2
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M.W.
|
Catalog Number
|
|
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16:0-18:1
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Palmitoyl
|
Oleoyl
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784.00
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840034
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|
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16:0-18:2
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Palmitoyl
|
Linoleoyl
|
781.98
|
840060
|
|
|
16:0-20:4
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Palmitoyl
|
Arachidonoyl
|
806.01
|
840061
|
|
|
16:0-22:6
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Palmitoyl
|
Docosahexaenoyl
|
830.03
|
840062
|
|
|
18:0-18:1
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Stearoyl
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Oleoyl
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812.05
|
840039
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|
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18:0-18:2
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Stearoyl
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Linoleoyl
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810.04
|
840063
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|
|
18:0-20:4
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Stearoyl
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Arachidonoyl
|
834.06
|
840064
|
|
|
18:0-22:6
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Stearoyl
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Docosahexaenoyl
|
858.08
|
840065
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Phosphatidylserine (Symmetric Fatty Acid)
1,2-Diacyl-sn-Glycero-3-[Phospho-L-Serine] (Sodium Salt)
| Carbon
Number |
Product |
M.W. |
Catalog
Number |
|
| 6:0 |
Dicaproyl |
477.42 |
840030 |
|
| 8:0 |
Dioctanoyl |
533.53 |
840031 |
|
| 10:0 |
Dicapryl |
589.64 |
840036 |
|
| 12:0 |
Dilauroyl |
645.75 |
840038 |
|
| 14:0 |
Dimyristoyl |
701.85 |
840033 |
|
| 16:0 |
Dipalmitoyl |
757.96 |
840037 |
|
| 16:0 [(CH3)4] |
Diphytanoyl |
870.18 |
850408 |
|
| 18:0 |
Distearoyl |
814.07 |
840029 |
|
| 18:1 |
Dioleoyl |
810.04 |
840035 |
|
| 18:2 |
Dilinoleoyl |
806.01 |
840040 |
|
| 20:4 |
Dierucoyl |
854.05 |
840066 |
|
| 22:6 |
Didocosa -hexaenoyl |
902.09
|
840067 |