- Avanti Polar Lipids

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Synthetic Products

1,2-Diacyl-3-Trimethylammonium-Propane (TAP)

Purity >99%

Typical TAP Structure

1,2-Distearoyl-3-Trimethylammonium-Propane (Chloride Salt)

Chain	Acyl Group	M.W.	Avanti Number
14:0	Dimyristoyl	590.37	890860	Product Data
16:0	Dipalmitoyl	646.48	890870	Product Data
18:0	Distearoyl	702.59	890880	Product Data
18:1	Dioleoyl (DOTAP)	698.55	890890	Product Data
18:1	Dioleoyl (DOTAP) Methyl Sulphate Salt*	774.19	890895	Product Data
18:1	Fluorescent (DOTAP)	710.34	810890	Product Data

* Methyl Sulphate salt has been shown to have higher transfection efficiency in vivo.

cGMP
18:1	TAPaCl (GMP)	698.55	770890	Product Data

References:

Lamellarity of cationic liposomes and mode of preparation of lipoplexes
affect transfection efficiency.
Zuidam NJ, Hirsch-Lerner D, Margulies S, Barenholz Y.
Biochim Biophys Acta. 1999 Jul 15;1419(2):207-20.
[PubMed]
Electrostatic parameters of cationic liposomes commonly used for gene delivery
as determined by 4-heptadecyl-7-hydroxycoumarin.
Zuidam NJ, Barenholz Y.
Biochim Biophys Acta. 1997 Oct 23;1329(2):211-22.
[PubMed]